Automated brain tumor segmentation is crucial for aiding brain disease diagnosis and evaluating disease progress. Currently, magnetic resonance imaging (MRI) is a routinely adopted approach in the field of brain tumor segmentation that can provide different modality images. It is critical to leverage multi-modal images to boost brain tumor segmentation performance. Existing works commonly concentrate on generating a shared representation by fusing multi-modal data, while few methods take into account modality-specific characteristics. Besides, how to efficiently fuse arbitrary numbers of modalities is still a difficult task. In this study, we present a flexible fusion network (termed F2Net) for multi-modal brain tumor segmentation, which can flexibly fuse arbitrary numbers of multi-modal information to explore complementary information while maintaining the specific characteristics of each modality. Our F2Net is based on the encoder-decoder structure, which utilizes two Transformer-based feature learning streams and a cross-modal shared learning network to extract individual and shared feature representations. To effectively integrate the knowledge from the multi-modality data, we propose a cross-modal feature enhanced module (CFM) and a multi-modal collaboration module (MCM), which aims at fusing the multi-modal features into the shared learning network and incorporating the features from encoders into the shared decoder, respectively. Extensive experimental results on multiple benchmark datasets demonstrate the effectiveness of our F2Net over other state-of-the-art segmentation methods.

Multimodal medical image fusion aims to integrate complementary information from different modalities of medical images. Deep learning methods, especially recent vision Transformers, have effectively improved image fusion performance. However, there are limitations for Transformers in image fusion, such as lacks of local feature extraction and cross-modal feature interaction, resulting in insufficient multimodal feature extraction and integration. In addition, the computational cost of Transformers is higher. To address these challenges, in this work, we develop an adaptive cross-modal fusion strategy for unsupervised multimodal medical image fusion. Specifically, we propose a novel lightweight cross Transformer based on cross multi-axis attention mechanism. It includes cross-window attention and cross-grid attention to mine and integrate both local and global interactions of multimodal features. The cross Transformer is further guided by a spatial adaptation fusion module, which allows the model to focus on the most relevant information. Moreover, we design a special feature extraction module that combines multiple gradient residual dense convolutional and Transformer layers to obtain local features from coarse to fine and capture global features. The proposed strategy significantly boosts the fusion performance while minimizing computational costs. Extensive experiments, including clinical brain tumor image fusion, have shown that our model can achieve clearer texture details and better visual quality than other state-of-the-art fusion methods.

云南大学、锡根大学

重庆邮电大学、第三军医大学、重庆医科大学第二附属医院

Multi-modality image fusion (MMIF) entails synthesizing images with detailed textures and prominent objects. Existing methods tend to use general feature extraction to handle different fusion tasks. However, these methods have difficulty breaking fusion barriers across various modalities owing to the lack of targeted learning routes. In this work, we propose a multi-scenario feature joint learning architecture, MLFuse, that employs the commonalities of multi-modality images to deconstruct the fusion progress. Specifically, we construct a cross-modal knowledge reinforcing network that adopts a multipath calibration strategy to promote information communication between different images. In addition, two professional networks are developed to maintain the salient and textural information of fusion results. The spatial-spectral domain optimizing network can learn the vital relationship of the source image context with the help of spatial attention and spectral attention. The edge-guided learning network utilizes the convolution operations of various receptive fields to capture image texture information. The desired fusion results are obtained by aggregating the outputs from the three networks. Extensive experiments demonstrate the superiority of MLFuse for infrared-visible image fusion and medical image fusion. The excellent results of downstream tasks (i.e., object detection and semantic segmentation) further verify the high-quality fusion performance of our method. The code is publicly available at https://github.com/jialei-sc/MLFuse

The successful fusion of 3-D multi-modal medical images depends on both specific characteristics unique to each imaging mode as well as consistent spatial semantic features among all modes. However, the inherent variability in the appearance of these images poses a significant challenge to reliable learning of semantic information. To address this issue, this paper proposes a nested self-supervised learning framework for 3-D semantic segmentation-driven multi-modal medical image fusion. The proposed approach utilizes contrastive learning to effectively extract specified multi-scale features from each mode using U-Net (CU-Net). Subsequently, it employs geometric spatial consistency learning through a fusion convolutional decoder (FCD) and a geometric matching network (GMN) to ensure consistent acquisition of semantic representation within the same 3-D regions across multiple modalities. Additionally, a hybrid multi-level loss is introduced to facilitate the learning process of fused images. Ultimately, we leverage optimally specified multi-modal features for fusion and brain tumor lesion segmentation. The proposed approach enables cooperative learning between 3-D fusion and segmentation tasks by employing an innovative nested self-supervised strategy, thereby successfully striking a harmonious balance between semantic consistency and visual specificity during the extraction of multi-modal features. The fusion results demonstrated a mean classification SSIM, PSNR, NMI,and SFR of 0.9310, 27.8861, 1.5403, and 1.0896 respectively. The segmentation results revealed a mean classification Dice, sensitivity (Sen), specificity (Spe), and accuracy (Acc) of 0.8643, 0.8736, 0.9915, and 0.9911 correspondingly. The experimental findings demonstrate that our approach outperforms 11 other state-of-the-art fusion methods and 5 classical U-Net-based segmentation methods in terms of 4 objective metrics and qualitative evaluation. The code of the proposed method is available at https://github.com/ImZhangyYing/NLSF.

Positron Emission Tomography (PET) and Computed To-mography (CT) are routinely used together to detect tumors. PET/CT segmentation models can automate tumor delineation, however, current multimodal models do not fully exploit the complementary information in each modality, as they either concatenate PET and CT data or fuse them at the decision level. To combat this, we propose Mirror U-Net, which replaces traditional fusion methods with multi-modal fission by factorizing the multimodal representation into modality-specific decoder branches and an auxiliary multimodal decoder. At these branches, Mirror U-Net assigns a task tailored to each modality to reinforce unimodal features while preserving multimodal features in the shared representation. In contrast to previous methods that use either fission or multi-task learning, Mirror U-Net combines both paradigms in a unified framework. We explore various task combinations and examine which parameters to share in the model. We evaluate Mirror U-Net on the AutoPET PET/CT and on the multimodal MSD BrainTumor datasets, demonstrating its effectiveness in multimodal segmentation and achieving state-of-the-art performance on both datasets. Code: https://github.com/Zrrr1997

If unaligned multimodal medical images can be simultaneously aligned and fused using a single-stage approach within a unified processing framework, it will not only achieve mutual promotion of dual tasks but also help reduce the complexity of the model. However, the design of this model faces the challenge of incompatible requirements for feature fusion and alignment. To address this challenge, this paper proposes an unaligned medical image fusion method called Bidirectional Stepwise Feature Alignment and Fusion (BSFA-F) strategy. To reduce the negative impact of modality differences on cross-modal feature matching, we incorporate the Modal Discrepancy-Free Feature Representation (MDF-FR) method into BSFA-F. MDF-FR utilizes a Modality Feature Representation Head (MFRH) to integrate the global information of the input image. By injecting the information contained in MFRH of the current image into other modality images, it effectively reduces the impact of modality differences on feature alignment while preserving the complementary information carried by different images. In terms of feature alignment, BSFA-F employs a bidirectional stepwise alignment deformation field prediction strategy based on the path independence of vector displacement between two points. This strategy solves the problem of large spans and inaccurate deformation field prediction in single-step alignment. Finally, Multi-Modal Feature Fusion block achieves the fusion of aligned features. The experimental results across multiple datasets demonstrate the effectiveness of our method.

U-Net is a widely used model for medical image segmentation, renowned for its strong feature extraction capabilities and U-shaped design, which incorporates skip connections to preserve critical information. However, its decoders exhibit information-specific preferences for the supplementary content provided by skip connections, instead of adhering to a strict one-to-one correspondence, which limits its flexibility across diverse tasks. To address this limitation, we propose the Task-Adaptive Mixture of Skip Connections (TA-MoSC) module, inspired by the Mixture of Experts (MoE) framework. TA-MoSC innovatively reinterprets skip connections as a task allocation problem, employing a routing mechanism to adaptively select expert combinations at different decoding stages. By introducing MoE, our approach enhances the sparsity of the model, and lightweight convolutional experts are shared across all skip connection stages, with a Balanced Expert Utilization (BEU) strategy ensuring that all experts are effectively trained, maintaining training balance and preserving computational efficiency. Our approach introduces minimal additional parameters to the original U-Net but significantly enhances its performance and stability. Experiments on GlaS, MoNuSeg, Synapse, and ISIC16 datasets demonstrate state-of-the-art accuracy and better generalization across diverse tasks. Moreover, while this work focuses on medical image segmentation, the proposed method can be seamlessly extended to other segmentation tasks, offering a flexible and efficient solution for diverse applications.

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Centre des Mat´eriaux、Centre de Mise en Forme des Mat´eriaux、Centre de Morphologie Math´ematique

Transformers have recently gained considerable popularity for capturing long-range dependencies in the medical image segmentation. However, most transformer-based segmentation methods primarily focus on modeling global dependencies and fail to fully explore the complementary nature of different dimensional dependencies within features. These methods simply treat the aggregation of multi-dimensional dependencies as auxiliary modules for incorporating context into the Transformer architecture, thereby limiting the model’s capability to learn rich feature representations. To address this issue, we introduce the Dual Attention Encoder with Joint Preservation (DANIE) for medical image segmentation, which synergistically aggregates spatial-channel dependencies across both local and global areas through attention learning. Additionally, we design a lightweight aggregation mechanism, termed Joint Preservation, which learns a composite feature representation, allowing different dependencies to complement each other. Without bells and whistles, our DANIE significantly improves the performance of previous state-of-the-art methods on five popular medical image segmentation benchmarks, including Synapse, ACDC, ISIC 2017, ISIC 2018 and GlaS.

在DRIVE数据集上的改进效果预估：

Medical image segmentation methods based on deep learning network are mainly divided into CNN and Transformer. However, CNN struggles to capture long-distance dependencies, while Transformer suffers from high computational complexity and poor local feature learning. To efficiently extract and fuse local features and long-range dependencies, this paper proposes Rolling-Unet, which is a CNN model combined with MLP. Specifically, we propose the core R-MLP module, which is responsible for learning the long-distance dependency in a single direction of the whole image. By controlling and combining R-MLP modules in different directions, OR-MLP and DOR-MLP modules are formed to capture long-distance dependencies in multiple directions. Further, Lo2 block is proposed to encode both local context information and long-distance dependencies without excessive computational burden. Lo2 block has the same parameter size and computational complexity as a 3×3 convolution. The experimental results on four public datasets show that Rolling-Unet achieves superior performance compared to the state-of- the-art methods.